Liver in liver function is observed with increasing in

Liver plays a major role in
regulating insulin clearance and maintaining post-prandial glucose levels and
it is evident that aminotransferases is one of the markers of the healthy
hepatocytes 32 and any alteration in liver function is observed with increasing
in ALT & AST levels after alloxan induction 33,34. Table 6 exemplifies
the results of liver markers during diabetes and after treatment with Annona cherimola. Elevation of SGOT,
SGPT and ALP enzyme levels were observed after alloxan induction which may be
due to the destruction of liver cells causing release of these enzymes in
cytosol into the blood stream 35. Treatment of diabetic rats with aqueous
leaf extract of Annona cherimola with
concentration 250 and 500 mg/kg b.w caused a reduction in the activity of these
enzymes by SGOT 41% & 49%; SGPT 14% & 37%; ALP 35% & 53%
respectively. The results are on par with the standard drug treated groups. Herbal
medicines has the capacity to reduce the complication associated with diabetes
is shown in many studies 36.

3.9. Effect of Annona cherimola extracts tissue
antioxidant enzymes

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is an important defense enzyme that catalysis the dismutation of superoxide
radicals. Enzyme catalysis is the hemoprotein that catalyses the decline of
hydrogen peroxide and defends the tissues from the effect of hydroxyl radicals 37.
The improvement in the liver SOD and CAT after treatment with aqueous leaf
extract of Annona cherimola (250 and
500 mg/kg b.w) indicates its beneficial action of the extract. The results of
antioxidant present in diabetic treated rats with aqueous leaf extract of Annona cherimola of 250 and 500 mg/kg
b.w is as similar to the action with standard drug glibenclamide (10 mg/kg
b.w). Similar results were observed in previous reports of antidiabetic effect
of Dillenia indica L. leaves in
diabetic rats 38.

4. Conclusion

the present study an attempt is being made to identify the effect of Annona cherimola over complication
associated with diabetes by improving radical scavenging ability in diabetic
rats. Relationship between body temperature during metabolic changes in
diabetic condition was analyzed and the results reveled that imaging process
can also be used to identify the abnormalities and can be a valuable tool for