Out of over 100 cancers, characterized by abnormal cell growth, Prostate Cancer (PC) remains one of the most prevalent malignancies in males. Due to PC’s complex underlying genetic code and it’s involvement with multiple susceptibility genes such as BRCA1 and BRCA2, extensive investigations have been contrived in order to investigate the potential links and possible correlation between Nucleotide excision repair (NER) gene polymorphisms and relative PC risk.
Some studies consumated that there could possibly be an existing correlation between PC and single nucleotide polymorphisms (SNPs) in protein-coding genes involved in NER. However, most studies have investigated only single SNPs among XP genes involved in NER that were initially identified in patients with xeroderma pigmentosum. The consequent results were very controversial and thus unreliable.
Out of 94 SNPs located in 7 XP genes a total of 15 SNPs were evaluated in 720 patients with PC (age range: 41–96, mean age: 68.3) and then analysed alongside 1121 healthy adults (age range: 35–92, mean age: 64.6) in Poland.
From the 15 SNPs studied, it was revealed that only 1 SNP in XPD correlated with PC risk. Furthermore, Rs1799793 (Asp312Asn) AG genotype (OR =2.60; p b0.001) presented a heightened risk of PC and a further increase in PC risk amidst the AA genotype (OR =5.31; p b0.0001) compared to the control population