Thiolated poly (acrylic acid)-250,thiolated PAA 250 (effect of thiolated polymer) using MRP2 substrate suforhodamine 101 explore more absorption from gut compared with thiolated PAA 250 and unthiolated PAA 250 thus indicates restrict action of MRP2 which was highest in duodenum this overall study i.
e. invivo and invitro was done on rat intestinal mucosa. Dipyridamole restrict P-gp activity which increased digoxin absorption and plasma level investigated on rat, the third generation inhibitor OC114-093(ONT-093) used for oral uptake of docetaxel.Polyethylene glycol, pluronics, tween 80, tween 20, thiomers vitamin E derivatives are used as polymeric P-gp inhibitors in oral bioavailability. Doxorubicin and PEG 300 restrict efflux transporters of P-gp activity in Caco-2 monolayers.
Polyacrylic acid and pluronic P investigated cell absorption of doxorubicin restricting by P-gp activity in Caco-2 monolayers. Copolymers poly 2-hydroxyethyl methacrylate-co-methyl (P-HEMA-co-MMA) were used to study swelling and relaxation behavior in experiments by Davidson and Peppas. All types of orally taken anticancer drugs found to be excreted by first metabolic process with cytochrome P450 and P-gp.